Durian is a strange and interesting fruit. It is one I do not personally enjoy and maybe that is a good thing after I came across this article.
The essence of the article is that a woman died and both alcohol and durian were found near her body. It is commonly believed in Thailand that to consume both alcohol and durian at the same time is dangerous and will cause death. Her neighbors reported she’d been consuming the two at the same time.
I couldn’t find any evidence online that backs up the claim, so you are probably pretty safe with eating durian and having a few beers but don’t say I didn’t warn you.
But I would say the main danger of Durian is the smell, especially when you consider it could get you kicked off a bus or out of a mall!